Clinical trials and real-world registries demonstrate that cannabinoid therapies may help modulate severe behavioral dysregulation, anxiety, and sleep disruption in pediatric autism spectrum disorder. Because children possess distinct neurodevelopmental sensitivities and hepatic metabolic profiles, cannabinoid treatment requires specialized physician supervision, precise whole-plant formulation selection, and gradual micro-titration. Board-certified family physician Dr. Benjamin Caplan provides a comprehensive breakdown of clinical mechanisms, peer-reviewed evidence, and strict safety guidelines for families and clinicians.